Training and care

How To Review Parents DNA Results

In this article we explain various dna results and how to interpret them.

How To Review Parents DNA Results

If you are looking at a pup where the breeder guaranteed parentage (that mum and dad are who they say they are) start with it first. If that doesn’t apply to you, skip this step.

For this to be relevant your puppy will have been dna swabbed by the breeders vet and the sample sent away under their individual microchip number.

Typically, parentage test results come with three possible outcomes. Your dog’s test will be returned with one of the three.

These outcomes are:

  • Qualifies: The genetic test revealed that the relationship between your dog and their proposed parentage is likely true.
  • Excluded: The genetic test revealed that the relationship between your dog and their proposed parentage is likely untrue.
  • Inconclusive: There is not enough genetic data to come to a conclusive decision on parentage. Further testing may be offered, especially if the potential sires are related.

—————————————————

Reading the parents disease dna testing (this one is a must)

Autosomal-Recessive Results

These include but aren’t limited too

For poodles 

  • Congenital Macrothrombocytopenia
  • Congenital Methemoglobinemia (Poodle and Pomeranian Type)
  • Degenerative Myelopathy
  • Gangliosidosis GM2 (Poodle Type)
  • Osteochondrodysplasia (Min Poodle Type)
  • Progressive Rod Cone Degeneration (prcd) - PRA
  • von Willebrand's Disease Type

Cocker spaniels 

  • Acral Mutilation Syndrome (SPANIEL & POINTER TYPE)
  • Autosomal Hereditary Recessive Nephropathy
  • Bernard-Soulier Syndrome (Cocker Spaniel Type)
  • Exercise Induced Collapse (Retriever Type)
  • Phosphofructokinase Deficiency (Spaniel Type)
  • Progressive Rod Cone Degeneration (prcd) - PRA

Cavalier King Charles spaniels 

  • Airway Distress Syndrome (ADAMTS3) - Risk Marker
  • Congenital Macrothrombocytopenia
  • Curly Coat Dry Eye Syndrome (Cavalier Type)
  • Degenerative Myelopathy
  • Episodic Falling Syndrome (Cavalier Type)
  • Myxomatous Mitral Valve Disease (ALL MMVD Risk Variants)

Labradoodle 

  • Achromatopsia (Labrador Type)
  • Autosomal Hereditary Recessive Nephropathy
  • Centronuclear Myopathy (Labrador Retriever Type)
  • Cone-Rod Dystrophy I - PRA (crd -4/cord I)
  • Congenital Macrothrombocytopenia
  • Congenital Methemoglobinemia (Poodle and Pomeranian Type)
  • Congenital Myasthenic Syndrome (Labrador Retriever Type)
  • Cystinuria (SLC3A1) Labrador Retriever Type
  • Degenerative Myelopathy
  • Ehlers-Danlos Syndrome (Labrador Retriever Type), Variant 2
  • Ehlers-Danlos Syndrome (Labrador Type)
  • Elliptocytosis B-spectrin (Labrador Retriever/Poodle Type)
  • Exercise Induced Collapse (Retriever Type)
  • Gangliosidosis GM2 (Poodle Type)
  • Globoid Cell Leukodystrophy/Krabbe’s Disease
  • Hereditary Nasal Parakeratosis/Dry Nose (Labrador Retriever Type)
  • Hyperuricosuria
  • Ivermectin Sensitivity MDR1 (Multi Drug Resistance)
  • Macular Corneal Dystrophy (Labrador Type)
  • Malignant Hyperthermia
  • Myotonia Congenita (Labrador Retriever Type)
  • Myotubular Myopathy X-Linked (Labrador Retriever Type)
  • Narcolepsy (Labrador)
  • Neonatal Encephalopathy (Poodle Type)
  • Osteochondrodysplasia (Min Poodle Type)
  • Phosphofructokinase Deficiency (Spaniel Type)
  • Progressive Rod Cone Degeneration (prcd) - PRA
  • Pyruvate Kinase Deficiency (Labrador Type)
  • Skeletal Dysplasia 2 (Mild Disproportionate Dwarfism)
  • Stargardt Disease (Retinal Degeneration)
  • von Willebrand's Disease Type

If you receive a test that details your dog’s predisposition for genetic conditions, search for the autosomal-recessive results.

In this section, you will find three results: clear, carrier, or affected.

Clear: Your dog does not have a copy of the abnormal gene you tested for. They wont develop this condition and will not pass on a genetic predisposition to puppies.

 Carrier: Your dog has one copy of the abnormal gene you tested for. They are unlikely to develop this condition but may pass on a genetic predisposition to puppies.

 Carriers should only ever be bred to a clear partner 

 Affected: Your dog has two copies of the abnormal gene you tested for. They will likely be affected by the condition and will pass on an abnormal gene to puppies.

 Should not be bred at all in my opinion but if they were the partner has to be dna clear 

—————————————————

Review Autosomal-Dominant Results

Autosomal-dominant results don’t look like the autosomal-recessive results.

Your dog’s results will be either clear, heterozygous affected, or homozygous affected. 

Clear: Your dog has no copies of the abnormal gene in question, and they will not develop the condition. They will not pass an abnormal gene to puppies. 

Heterozygous affected: Your dog has one normal gene and one abnormal gene for the condition you’re testing for. They will likely develop the condition and could pass it down to puppies. 

Homozygous affected: Your dog has both abnormal genes for the condition. They will likely develop the condition and will pass an abnormal gene to their puppies.